M.S. Yeoman, A. Cizinauskas, C. Lowry, G. Vincent, S. Collins, D. Simpson
Continuum Blue, Tredomen, Ystrad Mynach, United Kingdom
Corin Group, Cirencester, United Kingdom
Imoprhics, Manchester, United Kingdom
Bone resorption around hip stems, in particular periprosthetic bone loss, is a common observation post-operatively. A number of factors influence the amount of bone loss over time and the mechanical environment following total hip replacement (THR) is important. Conventional long stem prostheses have been shown to transfer loads distally, resulting in bone loss of the proximal femur. More ...
C. Romero, M. Mujeeb-U-Rahman
California Institute of Technology, Pasadena, CA, USA
Implantable biosensors have the potential to revolutionize the healthcare industry by allowing patients and their health care providers to continuously monitor blood pH levels, pCO2, proteins, metabolites, and a wide variety of other biomolecules. These devices need to operate completely wirelessly to be used for long term monitoring. Metal coils are attractive candidates for wireless power ...
D. Iber, J. Vollmer, D. Menshykau
Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland
Most models of biological pattern formation are simulated on continuous domains even though cells are discrete objects that provide internal boundaries to the diffusion of regulatory components. In our previous papers on simulating organogenesis in COMSOL Multiphysics® (Germann et al COMSOL Multiphysics® Conf Procedings 2011; Menshykau and Iber, COMSOL Multiphysics® Conf Proceedings 2012) we ...
V. Di Virgilio, A. Coll, S. Bermejo, and L. Castañer
Universitat Politecnica de Catalunya, Barcelona, Spain
In this work we want to explore some techniques, microfluidic and electrospray-ionization based, suitable for dynamic microarrays\' fabrication. The fabrication techniques are based on manipulation and self-assembly of selective coated micro and nanobeads. The simulation will include electro-osmotic flow, species transport, and electrostatics.
J. Kantor, Y. Feng, C. Acosta, E. Massingill
University of Texas at San Antonio, San Antonio, TX, USA
Cryotherapy and thermotherapy are common methods of treatment for acute injuries ranging from ankle sprains to complex surgery. The idea behind such treatment is that a change in temperature will reduce pain and constrict fluctuations in blood flow at the targeted area. The purpose of this study is to simulate the vascularized tissue reaction and the resulting blood flow fluctuation from thermal ...
Q.A. Chaudhry, M. Hanke, and R. Morgenstern
School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
Karolinska Institutet, Stockholm, Sweden
The mathematical modeling of the diffusion and reaction of toxic compounds in mammalian cells is tough task due to their very complex geometry. The heterogeneity of the cell, particularly the cytoplasm, and the variation of the cellular architecture, greatly affects the behavior of these toxic compounds. Homogenization techniques have been implemented for the numerical treatment of the model. ...
P. Krastev, and B. Tracey
Neurometrix, Inc., Waltham, Massachusetts, USA
Nerve localization is important for applications in regional anesthesia. Localization is achieved by stimulating the nerve with an electric field produced by a current from a needle inserted into the body of the patient, close to the target nerve. Modeling of the electric field in close proximity to the nerve may help to explain observed variations in threshold currents and can help to ...
Compensating Spatial Variability of Quantity Index in 2D Electrical Impedance Tomography: COMSOL Multiphysics Study
S. Oh, and R. Sadleir
Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA
In Electrical Impedance Tomography (EIT), an array of surface electrodes is used to inject current and measure the resulting voltages to non-invasively obtain conductivity distributions of objects. The system can be easily implemented as a device that monitors hemorrhage, respiration, gastric emptying or brain activities.The Quantity Index (QI), an integral measure of reconstructed images, can be ...
A.Torrents, N. Godino, F.J. del Campo, F.X. Muñoz, and J. Mas
Universitat Autònoma de Barcelona, Spain
Microbia Fuel Cells (MFC’s) are complex environments where electrochemical, physical and biological aspects must be considered together. In this work we present a 1D model partially describing a Shewanella oneidensis MFC that degrade sodium lactate [lactate -> Acetate + CO2 + 2H+ + 2e-]. The model, simulated using COMSOL, focuses on pH implications of the MFC operation. Release of protons ...
A. Gerisch, S. Tiburtius, Q. Grimal, and K. Raum
Technische Universität Darmstadt, Darmstadt, Germany
Laboratoire d’Imagerie Paramétrique, UPMC, Paris, France
Julius Wolff Institut & Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany
Musculoskeletal mineralized tissues (MMTs), e.g. bone, are hierarchical composite materials. Their effective elastic properties at different scales are of interest for computational studies of the MMT’s response to mechanical loading but also to realistically simulate implant osseointegration. We combine multi-scale and multi-modal experimental techniques with mathematical modelling of MMTs ...