K. Cluff, H. Mehraein, B. Jayakumar
Department of Bioengineering, Wichita State University, Wichita, KS, USA
Department of Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA
Background: Peripheral arterial disease (PAD) is characterized by atherosclerotic blockages of the arteries supplying the lower extremities, which cause a progressive accumulation of ischemic injury to the skeletal muscles of the lower limbs. Despite revascularization treatment intervention some PAD patients require follow up secondary treatment due to a continued decline in limb function, ...
D. Gasperino 
 Intellectual Ventures Laboratory, Bellevue, WA, USA
INTRODUCTION: Point of care diagnostics aimed at low-resource settings need to be relatively simple, robust and low-cost. The most commonly-used diagnostic platform in these settings is the lateral flow assay (LFA). LFAs are paper-based immunoassays designed to perform on-strip binding with analytes in patient samples in order to generate a visual signal if disease-specific antigen is ...
H.H. Chen-Mayer, and R. Tosh
Ionizing Radiation Division, National Institute of Standards and Technology, Gaithersburg, Maryland, USA
Water calorimetry is employed to establish a primary reference standard for radiation dosimetry by measuring the temperature rises in a water phantom (a cube of about 30 cm x 30 cm x 30 cm) subjected to a beam of ionizing radiation. We use COMSOL Multiphysics to model the system using the Heat Transfer module and the Incompressible Navier-Stokes module with a geometry of 2D-axial ...
D. Iber, D. Menshykau, and P. Germann
Department of Biosystems Science and Engineering
Organogenesis is a tightly regulated process that has been studied experimentally for decades. Computational models can help to integrate available knowledge and to better understand the underlying regulatory logic. We are currently studying mechanistic models for the development of limbs, lungs, kidneys, and bone. We have tested a number of alternative methods to solve our spatio-temporal ...
An Elastic and Hyperelastic Material Model of Joint Cartilage - Calculation of the Pressure Dependent Material Stress in Joint Cartilage
T. Reuter, and M. Hoffmann
Research Centre of Medical Technology and Biotechnology
Bad Langensalza, Germany
In this paper we introduce a elastic and hyperelastic model to describe the pressure dependent material stress in joint cartilage. We used the pressure dependent E-modulus E = f(s) to calculate the material stress. E = f(s) is a degree 4 polynomial . The indentor was pressed 0.4 mm into the tissue. The results show that the maximal stress at the contact zone between indentor and cartilage ...
Simulation and Design of a Microfluidic Respirometer for Semi-Continuous Amperometric Short Time Biochemical Oxygen Demand (BODST) Analysis
F.J. del Campo, A. Torrents, J. Mas, F.X. Muñoz
Instituto de Microelectronica de Barcelona, IMB-CNM (CSIC), Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
Departement de Genètica i Microbiologia, Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
Introduction: This work presents the design of a novel flow cell based miniaturized electrochemical respirometer to monitor organic content in water samples semi-continuously, in contrast to current Biochemical Oxygen Demand, BOD, methods. Simulation techniques has been used to parameterize and optimize aspects such as height and length of the channels, materials and thickness, flow and oxygen ...
S. Curet, M. Mazen Hamoud-Agha
GEPEA, UMR 6144, CNRS, ONIRIS, Université de Nantes, Nantes, France
In this study, COMSOL®4.2a is used to model a microwave heating process in a TE10 rectangular waveguide. The sample consists of a small cylindrical Ca-alginate gel (D = 8 mm, H = 10 mm) inoculated with bacteria Escherichia Coli K12. The sample is placed along the microwave propagation direction into the waveguide. Maxwell’s equations and heat transfer are coupled to a microbial inactivation ...
L. Murtomäki, T. Kainuvaara
University of Helsinki, Helsinki, Finland
Drug therapy of the posterior segment of an eye is very challenging due to the difficult accessibility. Modern drugs often are large molecules, such as peptides, antibodies or oligonucleotides which are administrated, e.g. by intravitreous injections which requires clinical conditions. Computer modeling can be helpful in designing new and less invasive routes of drug administration. COMSOL is ...
M. Miliani, F. Piccagli, C. Silvestro
Medtronic Invatec S.p.A., Roncadelle, Italy
Introduction: Chronic arterial hypertension (HTN) is a pathological condition characterized by prolonged high level of arterial blood pressure causing major damages to several human body apparata. Renal sympathetic denervation (RDN) has been found to effectively reduce systemic blood pressure. Metallic electrodes can be placed on an endovascular device connected to external radio frequency (RF) ...
M. Huet ,
 Department of Biotechnology, CEA/Université Grenoble-Alpes, Grenoble, France
A microfluidic component was designed to collect blood from a finger prick by capillary flow and to perform biological analysis. It was used to perform ABO blood typing experiments in one step, the blood drop deposit, by agglutination of red blood cells (RBC) using embedded dried reagents. The present study is a first step in the modeling of the whole agglutination assay. Blood typing ...