Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Numerical Prediction of Particle Dynamics Within a Cytometer. Application to Counting and Sizing by Impendance Measurement

D. Isèbe[1]
[1]HORIBA Medical, Montpellier, France

This paper describes how to numerically tackle the problem of counting and sizing particles by impedance measurement in an orifice–electrode system. The model simulate the particle dynamics submitted to strong hydrodynamic stresses through a microorifice and compute the voltage pulses generated by the modification of the inner dielectric medium. This FSI problem is solved on a moving mesh by ...

Computational design and analysis of Microwave Tomography in Intracerebral Hemorrhage

Priyadarshini Natarajan [1], Rajkumar ElagiriRamalingam[1]
[1]Division of Biomedical Engineering, School of Biosciences and Technology, VIT University, Tamil Nadu, India

Intracerebral hemorrhage is a condition where a blood vessel in the brain ruptures and causes internal bleeding leading to hemorrhagic stroke. 800 in every 100,000 people suffer from stroke each year and it's one of the major causes of mortality worldwide. Diagnosis involves Neurological examination with MRI/CT scans which is costly and time consuming. Microwave Tomography (MWT) is proposed as a ...

Modeling of Nerve Stimulation Thresholds and Their Dependence on Electrical Impedance with COMSOL

P. Krastev[1], and B. Tracey[1]
[1]Neurometrix, Inc., Waltham, Massachusetts, USA

Nerve localization is important for applications in regional anesthesia. Localization is achieved by stimulating the nerve with an electric field produced by a current from a needle inserted into the body of the patient, close to the target nerve.  Modeling of the electric field in close proximity to the nerve may help to explain observed variations in threshold currents and can help to ...

Modeling Interface Response in Cellular Adhesion

G. Megali[1], D. Pellicanò[1], M. Cacciola[1], F. Calarco[1], D. De Carlo[1], F. Laganà[1], and F.C. Morabito[1]

[1]DIMET Department, Faculty of Engineering, University “Mediterranea” of Reggio Calabria, Reggio Calabria, Italy

Constitutive properties of living cells are able to withstand physiological environment as well as mechanical stimuli occurring within and outside the body. We examined fluid flow and Neo-Hookean deformation related to the rolling effect. A mechanical model to describe the cellular adhesion with detachment is here proposed. We developed a finite element analysis, simulating blood cells attached ...

Simulation of Chemotractant Gradients in Microfluidic Channels to Study Cell Migration Mechanism in Silico

P. Wallin[1], E. Bernson[1], J. Gold[1]
[1]Chalmers University of Technology, Applied Physics, Biological Physics, Gothenburg, Sweden

Cell migration of endothelial cells along gradients is an important process in vivo and an interesting target for cancer therapeutics. Microfluidics offer very powerful tools to study such migration processes in detail in the lab. In this study, we describe a model to simulate molecular gradients in a diffusion based microfluidic gradient generator and how a cell senses these gradients via cell ...

Virtual Thermal Ablation in the Head and Neck using COMSOL Multiphysics

U. Topaloglu[1], Y. Yan[2], P. Novak[2], P. Spring[3], J. Suen[3], and G. Shafirstein[3]
[1] Department of Information Technology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
[2]Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
[3]Department of Otolaryngology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Thermal ablation in the head and neck requires accurate thermal dose delivery to target tissue while protecting the structure and function of nearby tissue and organs. In this study, we present a method that allows importing Computed Tomography (CT) scans to COMSOL, in order to model accurately the expected pathological outcomes prior to thermal ablation treatment. Thermal ablation of a virtual ...

Prediction of Time of Death Using a Heat Transport Model

J.L. Smart[1], and M. Kaliszan[2]
[1]University of Kentucky, Paducah, KY, USA
[2]Medical University of Gdansk, Gdansk, Poland

COMSOL Multiphysics® 4.0 was used to study conductive and convective heat transfer from the human eyeball to the surrounding air. Postmortem temperature decay curves were collected in eyeballs of numerous human corpses. Of course, these curves represent only a portion of the complete temperature decay curve, since the pathologist is able to start collecting temperature data only after some ...

A Multiscale-Multiphysics Model for Axon Pathfinding Simulation, the Example of the Olfactory System

G. Naldi[1], G. Aletti[1], P. Causin[1]
[1]Dipartimento di Matematica ‘F. Enriques’, Università degli Studi di Milano, Milano, Italy

In the developing embryo, neurons form connections by projecting axons to appropriate target areas. The projection process includes neurite elongation, resulting from the assembly of new cytoskeletal material at the free end of the axon, a complex cascade of steering decisions, driven by biomechanical properties of the surrounding environment and by signals in it. In this work we focus on the ...

Computational Modeling to Study the Treatment of Cardiac Arrhythmias using Radiofrequency Ablation

A. González-Suárez[1], M. Trujillo[2], J. Koruth[3], A. D'Avila[3], E. Berjano[1]
[1]Biomedical Synergy, Electronic Engineering Department,Universitat Politècnica de Valencia, Valencia, Spain
[2]Instituto Universitario de Matemática Pura y Aplicada, Universitat Politècnica de Valencia, Valencia, Spain
[3]Helmsley Cardiac Electrophysiology Center, Mt SinaiMedicalCenter and School of Medicine, New York, NY, USA

Previous studies proposed using bipolar radiofrequency ablation across two catheters placed on opposing surfaces of the ventricular wall to create transmural lesions. 2D and 3D models were built and solved with COMSOL Multiphysics software. With these models, it was possible to study the temperature distribution and lesion geometry (Figure), to compare the potential of two ways of applying ...

Shear Stress Analysis in High-Throughput Dual-micropillar-based Microfluidic Platform

J.Borana[1], J.M.Lee[2], B.G.Chung[2]
[1]Indian Institute of Technology Guwahati, Guwahati, India
[2]Department of Mechanical Engineering, Sogang University, Seoul, Korea

We developed the dual-micropillar-based microfluidic platform to control cellular behavior. The 4×4 dual micro-pillar based platform consists of 16 circular-shaped outer micropillars and 8 saddle shaped inner-micropillars. We simulated various shapes of inner micropillars to analyze the shear stress inside the inner micropillar. Therefore, this dual-micropillar-based microfluidic platform could ...