Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Numerical Prediction of Particle Dynamics Within a Cytometer. Application to Counting and Sizing by Impendance Measurement

D. Isèbe[1]
[1]HORIBA Medical, Montpellier, France

This paper describes how to numerically tackle the problem of counting and sizing particles by impedance measurement in an orifice–electrode system. The model simulate the particle dynamics submitted to strong hydrodynamic stresses through a microorifice and compute the voltage pulses generated by the modification of the inner dielectric medium. This FSI problem is solved on a moving mesh by ...

Generation of Lofted NURBS Curves for 3D Model Generation with COMSOL Multiphysics®

R.T. Hart[1]
[1]Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA

A key challenge to finding quantitative solutions to biological problems is to model the complex 3D geometry of naturally occurring structures. Model generation often starts from serial sections from CT or MRI scans, confocal microscopy, or physical sectioning. In addition, prior to V4 of COMSOL Multiphysics®, there was a "loft" command to allow construction of 3D models from serial sections ...

Simulation of Radiation Dose Response in Phantom for CT

H. Chen-Mayer[1], R.E. Tosh[1]
[1]National Institute of Standards and Technology, Gaithersburg, MD, USA

The radiation dose produced by an x-ray CT scanner to the patient is conventionally referenced to measurements performed by an ionization chamber in a phantom. On a fundamental level, the radiation absorbed dose, J/kg, can be determined directly by the temperature rise in the absorbing material. We model the temperature response in a high density polyethylene (HDPE) phantom. Use of ...

Two Dimensional Blood Shear Modeling in a Blood Cooling Catheter

R. Sikorski[1], B. Chapman[1], T. Merrill[1]
[1]Rowan University, Glassboro, NJ, USA

A CFD cardiac catheter model was developed to determine the potential for blood hemolysis during administration of local therapeutic hypothermia using a CoolGuide catheter. In vivo animal studies have shown that mild hypothermia may reduce reperfusion injury often associated with heart attack. The CoolGuide Catheter System (CCS) delivers rapid local cooling through a cardiac catheter, reducing ...

Evaluation of Binary Mixture Models for 3D Printed Biosensors

J. Persad [1], S. Rocke [1], D. Ringis [1], A. Abdool [1],
[1] Department of Electrical and Computer Engineering, University of the West Indies, St. Augustine, Trinidad and Tobago

3D printing as applied to the area of electronics manufacture covers a broad range of traditional printing technologies [1]. The attraction in 3D printing lies in its potential to disrupt the traditional photolithographic/subtractive manufacturing line with simpler additive processes. Additive electronics manufacturing which utilises 3D printing techniques allow for fewer production steps and ...

Control-Release Anesthetics to Enable an Integrated Anesthetic-MSC Therapeutic

T. Maguire [1,2], M. Davis [1], I. Marrero-Berrios [1], C. Zhu [1], C. Gaughan [2], J. Weinberg [3], D. Manchikalapati [3], J. SchianodiCola [3], R. S. Schloss [1], J. Yarmush [3], M. Yarmush [1],
[1] Rutgers University, New Brunswick, NJ, USA
[2] BeauRidge Pharmaceuticals, New York, NY, USA
[3] Department of Anesthesiology, New York Methodist Hospital, Brooklyn, NY, USA

Introduction: While general anesthetics control pain via consciousness regulation, local anesthetics (LAs) act by decreasing sensation in the area of administration by blocking nerve transmission to pain centers. Perioperative intra-articular administration of LAs is a commonly employed procedure in orthopedic procedures to minimize patient surgical and post-surgical pain. LAs are also co ...

A Multiscale-Multiphysics Model for Axon Pathfinding Simulation, the Example of the Olfactory System

G. Naldi[1], G. Aletti[1], P. Causin[1]
[1]Dipartimento di Matematica ‘F. Enriques’, Università degli Studi di Milano, Milano, Italy

In the developing embryo, neurons form connections by projecting axons to appropriate target areas. The projection process includes neurite elongation, resulting from the assembly of new cytoskeletal material at the free end of the axon, a complex cascade of steering decisions, driven by biomechanical properties of the surrounding environment and by signals in it. In this work we focus on the ...

Electro Thermal Performance Prediction of Radio Frequency Ablation System for Efficient Cancer Treatment

C. Thiagarajan[1], V. Gnanasekar[2]
[1]ATOA Scientific Technologies Pvt Ltd, Whitefield, Bangalore, Karnataka, India.
[2]Perfint Healthcare Pvt. Ltd, T.Nagar, Chennai, India.

Cancer causes significant human deaths. Radiofrequency ablation is an encouraging procedure for cancer treatment. The objective is to demonstrate the multiphysics simulation methodology. This paper summarizes the problem , governing equations, methodology, assumptions, simulation results and discussion related to the thermal performance prediction of radio frequency ablation on a homogeneous ...

Shear Stress Analysis in High-Throughput Dual-micropillar-based Microfluidic Platform

J.Borana[1], J.M.Lee[2], B.G.Chung[2]
[1]Indian Institute of Technology Guwahati, Guwahati, India
[2]Department of Mechanical Engineering, Sogang University, Seoul, Korea

We developed the dual-micropillar-based microfluidic platform to control cellular behavior. The 4×4 dual micro-pillar based platform consists of 16 circular-shaped outer micropillars and 8 saddle shaped inner-micropillars. We simulated various shapes of inner micropillars to analyze the shear stress inside the inner micropillar. Therefore, this dual-micropillar-based microfluidic platform could ...

Biofluid-Structural Interaction in Abdominal Aortic Aneurysm for Predicting Timeline to Rupture: The Effect of Hypertension and Aorta Wall Material Properties - new

K. Cluff[1], H. Mehraein[1], G. Jayakumar[2]
[1]Bioengineering, Wichita State University, Wichita, KS, USA
[2]Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA

An abdominal aortic aneurysm (AAA) is a bulge formed in the large blood vessels that supply blood to the abdomen, pelvis, and legs. A fluid structure interaction model was developed in a 3D aortic aneurysm model, which was constructed from abdominal CT scan images. Combining medical imaging and computational fluid dynamics (CFD) in a time dependent study allowed the determination of wall ...