Application ID: 3924
Freeze-drying, or lyophilization, is a process for drying heat-sensitive substances such as foods, blood plasma, and antibiotics. The wet substance is frozen and then, through sublimation, ice (or some other frozen solvent) is removed in the presence of a high vacuum.
This example models the process of ice sublimation in a vial under vacuum-chamber conditions, a test case for many freeze-drying setups.
The model uses the arbitrary Lagrangian-Eulerian (ALE) method to compute the coupled heat and mass balances on a moving mesh attached to the advancing vapor-ice interface.
This application was built using the following:Heat Transfer Module
The combination of COMSOL® products required to model your application depends on the physics interfaces that define it. Particular physics interfaces may be common to several products (see the Specification Chart for more details). To determine the right combination of products for your project, you should evaluate all of your needs in light of each product\'s capabilities, consultation with the COMSOL Sales and Support teams, and the use of an evaluation license.