Drug Release from a Biomaterial Matrix
In this example, drug-release from a biomaterial matrix to damaged cell tissue is modelled.Specifically, a nerve guide delivers a regenerating drug to damaged nerve ends. The model involves detailed drug release kinetics, with rate expressions handling drug dissociation/association reactions as well as matrix degradation by enzyme catalysis. The enzyme reaction is described by Michaelis-Menten kinetics.
The detailed reaction/transport description used in this model allows for investigation of many design parameters relevant to the bioengineering. For instance, the effect of matrix degradation on drug release is presented as a function of time and geometry.
 |
A nerve guide delivers a regenerating drug to damaged nerve ends. The model involves detailed drug release kinetics of drug dissociation/association reactions as well as matrix degradation through enzyme catalysis described by Michaelis-Menten kinetics. |
Engineering Fields
- Mass Transfer
Application Areas
- Chemical Reaction Engineering
- Biotechnology
- Biomedical Engineering