R. Sisto, L. Cerini, D. Mambro, A. Moleti, F. Sanjust
INAIL Research, Monteporzio Catone, Italy
Università di Roma, Tor Vergata, Italy
The otoacoustic emissions (OAEs) are acoustic signals emitted by the inner ear as a consequence of the activity of a nonlinear feedback mechanism capable of amplifying the signal near to the hearing threshold level. The otoacoustic emissions can be used as an acoustic imaging of the cochlear functionality. They are used in clinics for screening purposes but due to the extreme variability between ...
A Multiscale-Multiphysics Model for Axon Pathfinding Simulation, the Example of the Olfactory System
G. Naldi, G. Aletti, P. Causin
Dipartimento di Matematica ‘F. Enriques’, Università degli Studi di Milano, Milano, Italy
In the developing embryo, neurons form connections by projecting axons to appropriate target areas. The projection process includes neurite elongation, resulting from the assembly of new cytoskeletal material at the free end of the axon, a complex cascade of steering decisions, driven by biomechanical properties of the surrounding environment and by signals in it. In this work we focus on the ...
A. Avanzini, D. Battini, M. Berardi
Università degli Studi di Brescia, Brescia, Italy
The complex behavior of biological prosthetic heart valves was simulated. A multiphysics computational approach was adopted using different modules of COMSOL Multiphysics: the LiveLink(TM) interface was used to exchange the valve geometry with CAD, Structural Mechanics Module to set loads, boundary conditions and implement anisotropic hyper-elastic constitutive laws for leaflet tissue, PDE to ...
B. Hari, S. Bakalis, P. Fryer
The University of Birmingham, School of Chemical Engineering, Edgbaston, Birmingham, United Kingdom
Worldwide attention in the computational modeling and simulation of the human intestine is increasing in order to help understand its complex behavior and improve health. Computational fluid dynamics is an essential tool to understand the mechanics and transport phenomena of the human intestine, thereby advancing the diagnosis and treatment of gastrointestinal related diseases. The aim of this ...
D. Iber, D. Menshykau
D-BSSE, ETH Zurich, Basel, Switzerland
Organogenesis is a tightly regulated process that has been studied experimentally for decades. We are developing mechanistic models for the morphogenesis of limbs, lungs, and kidneys with a view to integrate available knowledge and to better understand the underlying regulatory logic. Organ size changes dramatically during development, and tissues are composed of several layers that may expand ...
Simulation of Chemotractant Gradients in Microfluidic Channels to Study Cell Migration Mechanism in Silico
P. Wallin, E. Bernson, J. Gold
Chalmers University of Technology, Applied Physics, Biological Physics, Gothenburg, Sweden
Cell migration of endothelial cells along gradients is an important process in vivo and an interesting target for cancer therapeutics. Microfluidics offer very powerful tools to study such migration processes in detail in the lab. In this study, we describe a model to simulate molecular gradients in a diffusion based microfluidic gradient generator and how a cell senses these gradients via cell ...
A Simplified Numerical Model for Simulating Sliding Door and Surgical Staff Movement in an Operating Theater
Dipartimento di Energetica, Università di Firenze, Firenze, Italy
This paper deals with a numerical investigation on sliding door and people moving effects on the indoor climate of a standard ISO5 class OT with an ultraclean air filter system and a total ceiling unidirectional diffuser. A simple method to analyze the effects on the OT climate by different sliding door conditions combined with crossing persons and persons with a stretcher crossing is provided. ...
Simulation and Design of a Microfluidic Respirometer for Semi-Continuous Amperometric Short Time Biochemical Oxygen Demand (BODST) Analysis
F.J. del Campo, A. Torrents, J. Mas, F.X. Muñoz
Instituto de Microelectronica de Barcelona, IMB-CNM (CSIC), Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
Departement de Genètica i Microbiologia, Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
Introduction: This work presents the design of a novel flow cell based miniaturized electrochemical respirometer to monitor organic content in water samples semi-continuously, in contrast to current Biochemical Oxygen Demand, BOD, methods. Simulation techniques has been used to parameterize and optimize aspects such as height and length of the channels, materials and thickness, flow and oxygen ...
N.S. Lawand, J. van Driel, P.J. French
Electronic Instrumentation Laboratory (EILab), Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS), Delft University of Technology, Delft, The Netherlands
Delft University of Technology, Delft, The Netherlands
Cochlear Implants are implantable devices which bypasses the non-functional inner ear and directly stimulates the hearing nerve with electric currents thus enabling deaf people to experience sound again. Implant electrode array design is limited in electrode count, due to their large size in accordance to scala tympani (ST) with restrictions for deeper insertion in ST thus depriving access to low ...
I.M. Abdel-Motaleb, K. Ravanasa, K.J. Soderholm
Department of Electrical Engineering, Northern Illinois University, DeKalb, IL, USA
Department of Restorative Dental Sciences, College of Dentistry, University of Florida, Gainesville, FL USA
Studying teeth grinding behavior and other oral conditions requires the ability to accurately measure the pressure on the teeth. Placing a sensor in the mouth requires small size devices with powering and measurement techniques that do not hinder the normal life of the patient. To meet these requirements, we designed, using COMSOL, a small, easy to read MEMS capacitive force sensor, with ...